Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• antileishmanial drugs to such sites. Overall, drug targeting results in increased treatment efficacy and reduced toxicity, mostly by reducing drug doses and preventing its interaction with unwanted receptors [30][65]. In this scenario, active targeting happens by the functionalization of nanocarriers, making drug

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• time for passive and active drug targeting before particles are filtered out of the circulation system. Overall, it was shown that softer particles have an enhanced blood circulation time. The effects described were observed for different particle types (made from different materials) and also covered

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• considerations in the engineering of tumor-homing nanoparticles will be discussed below with an emphasis on increased lung tumor tissue localization. Current approaches for overcoming biological barriers and improved drug targeting Looking back at almost half a century of research on drug targeting, experimental

• also confirmed in an in vivo lung cancer mouse model [133]. Models for drug targeting via nanocarriers and ideas for the resolution of the main drawbacks regarding their performance are numerous. Only a choice of approaches was discussed in this section giving rational solutions for improving the

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• particles. In this way, a higher passive drug targeting effect can be achieved, which was explained by enhanced deformability. The enhanced shape flexibility should lead to a higher extravasation rate and less effective clearance mechanisms. This combination leads to an enhanced particle accumulation in the

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• therapeutic index. The use of nanomaterials has increased nowadays for more specific drug targeting and delivery, slowing down the dissolution rate of drugs, increasing therapeutic efficacy with the minimum dosage, and also by ceasing the premature loss of drugs through rapid clearance. Additionally, the

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• -patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and

• therapeutic efficacy, and safety studies. Keywords: drug delivery; drug targeting; endocytosis; medical; nanoparticles; superparamagnetic iron oxide nanoparticles (SPIONs); toxicity; Introduction Nanoencapsulation technologies have been researched over the past several decades and have been widely

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• . Keywords: cell receptors; drug targeting; endocytosis; nanoparticle corona; nanoparticle uptake; Introduction Nano-sized materials are widely studied in nanomedicine for their potential use as drug carriers, in imaging, and for diagnostic purposes [1][2][3]. Because of their size, they can interact with

• are affected by nanomaterial properties. In this way, nanomedicine design could be tuned to achieve the desired outcomes at cell level and engineer nanomaterials for more efficient drug targeting. Interaction of nano-sized materials at the cell surface. First, nanoparticles adhere at the plasma

pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging

• Saban Kalay,
• Yurij Stetsyshyn,
• Volodymyr Donchak,
• Khrystyna Harhay,
• Ostap Lishchynskyi,
• Halyna Ohar,
• Yuriy Panchenko,
• Stanislav Voronov and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2019, 10, 2428–2439, doi:10.3762/bjnano.10.233

• were tested for their delivery potential, which showed promising results for imaging and drug targeting applications [60][61]. As a continuation of the work [60][61], we demonstrate the potential of BNNTs as a novel pH-switchable fluorescent water-dispersed material for cellular imaging. To study the

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• obtained by dual drug targeting. Besides that, the magnetic and ligand targeting resulted in elevated cellular uptake of nanocapsules in glioma treatment [26]. Yang et al. successfully obtained targeted and traceable core–shell nanoparticles for carmustine (BCNU) delivery. These systems prolonged the half

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• ] or improved drug targeting. These optimization procedures are generally performed after particle assembly, since the nanoparticle formation is influenced by many parameters and often limited by minor changes in the experimental setup. However, several further surface modifications are well

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• for industrial usage, fuel additives for catalysis, additives in sunscreens for UV protection, or in the textile industry. One of the most promising fields of nanotechnology is drug delivery and drug targeting. Hydrophobic drugs are poorly soluble in biological media, other drugs lack gastric acid

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• the past decades, nanocarriers have been utilized for a variety of different applications. In the area of pharmaceuticals these versatile drug delivery devices enabled the directed transport of drug substances to specific tissues after modification of the particle surface with drug targeting ligands

• such as antibodies [1][2] and other proteins [3][4]. Aside the specific binding affinity, drug targeting is based on a passive accumulation mechanism that is controlled by particle size and surface characteristics of the colloids. Particles ranging in size between 50 and 300 nm accumulate in solid

• charged core particles were embedded into the HSA matrix by ethanolic desolvation of the protein [9]. By adjusting the reaction conditions of the desolvation procedure, particles of optimal size distribution and surface properties for drug targeting applications have been achieved. The USPIO load

Non-covalent and reversible functionalization of carbon nanotubes

• Antonello Di Crescenzo,
• Valeria Ettorre and
• Antonella Fontana

Beilstein J. Nanotechnol. 2014, 5, 1675–1690, doi:10.3762/bjnano.5.178

• ) do precipitate on addition of further polymer. The adsorption–desorption equilibrium is a real critical point when dealing with dilution steps (i.e., administration of drug targeting SWCNTs in the blood stream) as it is important to ascertain that a proper amount of the dispersant keeps covering the

Improvement of the oxidation stability of cobalt nanoparticles

• Celin Dobbrow and
• Annette M. Schmidt

Beilstein J. Nanotechnol. 2012, 3, 75–81, doi:10.3762/bjnano.3.9

• to their application potential in data storage [1] and in sensor applications [2], as well as for biomedical uses in therapy and diagnosis. By opening novel mechanisms for drug targeting [3], controlled drug release, hyperthermia [4][5] and imaging applications [6][7] there is a need for well